Anticorps Polyclonal de lapin anti-HOXC8

• Phare
• Validé par KD/KO

HOXC8 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IHC, IF, IP, CoIP, ELISA

Conjugaison

Non conjugué

Publications(11)

N° de cat : 15448-1-AP

Synonymes

homeobox C8, Homeobox protein Hox 3A, Homeobox protein Hox C8, Homeobox protein Hox-3A, Homeobox protein Hox-C8

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Galerie de données de validation

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  WB analysis of COLO 320 using 15448-1-AP

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 15448-1-AP (HOXC8 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of COLO 320 using 15448-1-AP

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 15448-1-AP (HOXC8 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of COLO 320 using 15448-1-AP

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 15448-1-AP (HOXC8 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of MDA-MB-453s using 15448-1-AP

  MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 15448-1-AP (HOXC8 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules COLO 320, cellules MDA-MB-453s

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 3 publications below
• WB: See 8 publications below
• IHC: See 3 publications below
• IF: See 2 publications below
• IP: See 1 publications below
• CoIP: See 1 publications below

Informations sur le produit

15448-1-AP cible HOXC8 dans les applications de WB, IHC, IF, IP, CoIP, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain, poulet, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: HOXC8 Protéine recombinante Ag7675
• Nom complet: homeobox C8
• Masse moléculaire calculée: 27 aa, 7 kDa
• Poids moléculaire observé: 33-38 kDa
• Numéro d’acquisition GenBank: BC053898
• Symbole du gène: HOXC8
• Identification du gène (NCBI): 3224
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

HOXC8 belongs to highly conserved subgroup of 39 genes housed into four clusters HOXA-HOXD within the superfamily of homeobox genes. HOX genes encode homeodomain- transcription factors that are responsible for regulating morphogenesis through axial patterning during embryogenesis. Homeobox C8 (HOXC8) is a transcription factor preferentially overexpressed in a large percentage of non-small cell lung carcinoma (NSCLC). HOXC8 participates NSCLC development by controlling CASP1 expression and pyroptosis (PMID: 40701951).

Publications

Species	Application	Title
mouse	IHC	Nature; Divergent transcriptional regulation of astrocyte reactivity across disorders.; Authors - Joshua E Burda
human	WB	J Exp Clin Cancer Res; N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1; Authors - Jing Li
human	WB,CoIP	iScience; DLX2 promotes osteosarcoma epithelial-mesenchymal transition and doxorubicin resistance by enhancing HOXC8-CDH2 axis; Authors - Boya Zhang
human	WB	Oncogenesis; HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer.; Authors - Houli Liu ; KD Validated
mouse	IF	iScience; Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.; Authors - Masami Shiimori
human	WB	Mol Carcinog; Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple-negative breast cancer.; Authors - Chen Gong ; KD Validated

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