Anticorps Polyclonal de lapin anti-HYAL1

HYAL1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 25179-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 25179-1-AP (same clone as 25179-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25179-1-AP (HYAL1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25179-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 25179-1-AP (same clone as 25179-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 25179-1-AP (HYAL1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25179-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 25179-1-AP (same clone as 25179-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 25179-1-AP (HYAL1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25179-1-PBS in a different storage buffer formulation.

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Informations sur le produit

25179-1-PBS cible HYAL1 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: HYAL1 Protéine recombinante Ag17943
• Nom complet: hyaluronoglucosaminidase 1
• Masse moléculaire calculée: 435 aa, 48 kDa
• Poids moléculaire observé: 60 kDa
• Numéro d’acquisition GenBank: BC035695
• Symbole du gène: HYAL1
• Identification du gène (NCBI): 3373
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Hyaluronic acid (HA) is a glycosaminoglycan that is believed to have numerous important biologic functions, including modulation of cell proliferation, migration, and differentiation, as well as the regulation of extracellular water and protein homeostasis. It is also an integral structural component of cartilage and other tissues and acts as a lubricant in joints. Hyaluronidases are a family of enzymes that catalyse the degradation of HA. In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYAL3, HYAL4 and HYAL5 (also known as SPAM1 or PH-20); plus a pseudogene, HYAL6 (also known as HYALP1). HYAL-1 is present in many tissues and is predominantly found in the plasma and urine (PMID: 16600643). In addition to its function in normal cellular hyaluronan turnover, human HYAL-1 is implicated in cancer proliferation, angiogenesis, and inflammatory diseases (PMID: 17503783).

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