Anticorps Recombinant de lapin anti-KIM-1/HAVCR1

KIM-1/HAVCR1 Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat, souris

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

230528C5

N° de cat : 83221-2-PBS

Synonymes

HAVCR1, KIM-1, TIM-1, 230528C5, CD365

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Galerie de données de validation

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  WB analysis using 83221-2-RR (same clone as 83221-2-PBS)

  Mouse kidney tissue was subjected to SDS PAGE followed by western blot with 83221-2-RR (HAVCR1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83221-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83221-2-RR

  Biolayer interferometry (BLl) kinetic assays of 83221-2-RR against Rat HAVCR1 were performed. The affinity constant is 0.477 nM.

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Informations sur le produit

83221-2-PBS cible KIM-1/HAVCR1 dans les applications de WB, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons rat, souris

• Réactivité: rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: KIM-1/HAVCR1 Protéine recombinante Eg0597
• Nom complet: hepatitis A virus cellular receptor 1
• Masse moléculaire calculée: 34 kDa
• Poids moléculaire observé: 72 kDa
• Numéro d’acquisition GenBank: NM_173149.2
• Symbole du gène: Havcr1
• Identification du gène (NCBI): 286934
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Kidney injury molecule 1 (KIM-1), also known as Hepatitis A virus cellular receptor 1 (HAVCR1), CD365, or T-cell immunoglobulin and mucin domain 1 (TIM-1), is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. KIM-1 acts as a membrane receptor for hepatitis A virus (HAV) (PMID: 9658108; 8861957). KIM-1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). KIM-1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that KIM-1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).

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