Anticorps Recombinant de lapin anti-Phospho-Histone H2A.X (Ser139)
Phospho-Histone H2A.X (Ser139) Recombinant Antibody for WB, IHC, IF/ICC, FC (Intra), Indirect ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain, rat, souris
Applications
WB, IHC, IF/ICC, FC (Intra), Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
5N19
N° de cat : 83307-2-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
83307-2-PBS cible Phospho-Histone H2A.X (Ser139) dans les applications de WB, IHC, IF/ICC, FC (Intra), Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris
Réactivité | Humain, rat, souris |
Hôte / Isotype | Lapin / IgG |
Clonalité | Recombinant |
Type | Anticorps |
Immunogène | Peptide |
Nom complet | H2A histone family, member X |
Masse moléculaire calculée | 15 kDa |
Poids moléculaire observé | 15 kDa |
Numéro d’acquisition GenBank | BC013416 |
Symbole du gène | Histone H2A.X |
Identification du gène (NCBI) | 3014 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Protein A purfication |
Tampon de stockage | PBS only |
Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
The histone variant H2AX is a major component of the DNA damage response (DDR), especially functioning in amplifying DNA damage signals. In response to DNA double-strand breaks (DSBs), H2AX is instantaneously phosphorylated at Ser139 (a form called cH2AX) by the kinases ATM and ATR. The phosphorylation of H2AX at Ser139, resulting in the formation of gamma-H2AX puncta in the nuclei, is an early event in the cellular response to DNA damage. Therefore, phospho-Histone H2A. X (Ser139) is also known as γH2AX. The phosphorylation site of H2AX, Ser139, has also been described as Ser140 in other literature, and they recognize the same amino acid site. (PMID: 22908299, PMID: 30106130, PMID:22941631)