Anticorps Polyclonal de lapin anti-Hepsin

Hepsin Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 51060-1-Ig

Synonymes

Hpn, AI788568, EC:3.4.21.106, Serine protease hepsin non-catalytic chain, TMPRSS 1

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Galerie de données de validation

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  WB analysis of human liver using 51060-1-Ig

  human liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse liver using 51060-1-Ig

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu hépatique humain, tissu hépatique de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

51060-1-Ig cible Hepsin dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: hepsin
• Masse moléculaire calculée: 47 kDa
• Poids moléculaire observé: 28 kDa
• Numéro d’acquisition GenBank: BC138809
• Symbole du gène: Hepsin
• Identification du gène (NCBI): 15451
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Hepsin is a type II transmembrane serine protease. It is primarily expressed in the liver but has also been detected in other tissues, including the prostate, kidney, and pancreas. Hepsin plays a crucial role in various physiological processes, such as cell growth, extracellular matrix remodeling, and tissue homeostasis. Notably, Hepsin has been implicated in cancer progression, particularly in prostate cancer, where its overexpression is associated with tumor metastasis and poor prognosis (PMID: 15324701, PMID: 18726901). Hepsin has been identified as a peptide of approximately 45 kDa representing the intact protein, and a fragment of about 28 kDa representing the cleaved extracellular domain (PMID: 19302215, PMID: 21734266).

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