Anticorps Polyclonal de lapin anti-ICAM5

ICAM5 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12759-1-PBS

Synonymes

---

Galerie de données de validation

• 

  WB analysis of mouse brain using 12759-1-AP (same clone as 12759-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12759-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse brain using 12759-1-AP (same clone as 12759-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12759-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

12759-1-PBS cible ICAM5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ICAM5 Protéine recombinante Ag3303
• Nom complet: intercellular adhesion molecule 5, telencephalin
• Masse moléculaire calculée: 924 aa, 97 kDa
• Poids moléculaire observé: 140 kDa
• Numéro d’acquisition GenBank: BC026338
• Symbole du gène: ICAM5
• Identification du gène (NCBI): 7087
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases. (PMID: 10402269; 17682049; 25300135)

{{ptg:RelatedPrimaryAntibodies}}