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Anticorps Polyclonal de lapin anti-ICMT

ICMT Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 17511-1-PBS

Synonymes

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using ICMT Polyclonal antibody (17511-1-AP)

    WB analysis using 17511-1-AP (same clone as 17511-1-PBS)

    Jurkat cells lysates were subjected to SDS PAGE followed by western blot with 17511-1-AP (ICMT antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17511-1-PBS in a different storage buffer formulation.

Informations sur le produit

17511-1-PBS cible ICMT dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet isoprenylcysteine carboxyl methyltransferase
Masse moléculaire calculée 32 kDa
Poids moléculaire observé 32-34 kDa
Numéro d’acquisition GenBankNM_012405
Symbole du gène ICMT
Identification du gène (NCBI) 23463
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Isoprenylcysteine carboxylmethyltransferase (ICMT), also known as PCCMT, is a multi-spanning endoplasmic reticulum integral membrane protein conserved among eukaryotic organisms. Methylation by ICMT is important for partitioning of CAAX proteins into lipid membranes as this modification neutralizes the negative charge on the carboxylate and increases the hydrophobicity of the modified protein (PMID: 25059662). Homozygous gene knockout of PPMT interferes with localization of K-Ras to the plasma membrane in mammalian cells and leads to the death of mouse embryos during gestation (PMID: 12141948).

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