Anticorps Recombinant de lapin anti-ICOS/CD278

ICOS/CD278 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241770G11

N° de cat : 98214-1-PBS

Synonymes

ICOS, CVID1, CD278, AILIM, Activation-inducible lymphocyte immunomediatory molecule

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Galerie de données de validation

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  FC experiment of human PBMCs using 98214-1-RR (same clone as 98214-1-PBS)

  1x10^6 untreated or PHA treated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were not fixed. This data was developed using the same antibody clone with 98214-1-PBS in a different storage buffer formulation.

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  FC experiment of human PBMCs using 98214-1-RR (same clone as 98214-1-PBS)

  1x10^6 PHA treated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98214-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98214-1-PBS cible ICOS/CD278 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: inducible T-cell co-stimulator
• Masse moléculaire calculée: 199 aa, 23 kDa
• Numéro d’acquisition GenBank: BC028210
• Symbole du gène: ICOS
• Identification du gène (NCBI): 29851
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Inducible T cell co-stimulator (ICOS) is related to the CD28 superfamily and is highly expressed on activated T cells as well as regulatory T cells and is crucial for the survival and function of T cells, Th2 cell differentiation, and lung inflammatory responses. Binding ICOS to ICOS-ligand (ICOS-L) activates a cascade of intracellular signaling molecules that prevent apoptosis and lead to the production of cytokines such as IL-4 and IL-13.

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