Anticorps Recombinant de lapin anti-ICOS/CD278

ICOS/CD278 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242639C3

N° de cat : 98341-1-PBS

Synonymes

242639C3, Activation-inducible lymphocyte immunomediatory molecule, Ailim, CCLP, CD278

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Galerie de données de validation

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  FC experiment of BALB/c spleen cells using 98341-1-RR (same clone as 98341-1-PBS)

  1x10^6 untreated or anti-CD3/CD28 treated BALB/c spleen cells were surface stained with 0.25 ug Anti-Mouse ICOS/CD278 Rabbit RecAb (98341-1-RR, Clone: 242639C3) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 488 Anti-Mouse CD3. Cells were not fixed. This data was developed using the same antibody clone with 98341-1-PBS in a different storage buffer formulation.

• 

  FC experiment of BALB/c spleen cells using 98341-1-RR (same clone as 98341-1-PBS)

  1x10^6 anti-CD3/CD28 treated BALB/c spleen cells were surface stained with 0.25 ug Anti-Mouse ICOS/CD278 Rabbit RecAb (98341-1-RR, Clone: 242639C3) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated BALB/c spleen cells were surface stained with 0.25 ug Anti-Mouse ICOS/CD278 Rabbit RecAb (98341-1-RR, Clone: 242639C3) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98341-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98341-1-PBS cible ICOS/CD278 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ICOS/CD278 Protéine recombinante Eg3198
• Nom complet: inducible T-cell co-stimulator
• Masse moléculaire calculée: 23kDa
• Numéro d’acquisition GenBank: NM_017480.2
• Symbole du gène: Icos
• Identification du gène (NCBI): 54167
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Inducible T cell co-stimulator (ICOS) is related to the CD28 superfamily and is highly expressed on activated T cells as well as regulatory T cells and is crucial for the survival and function of T cells, Th2 cell differentiation, and lung inflammatory responses. Binding ICOS to ICOS-ligand (ICOS-L) activates a cascade of intracellular signaling molecules that prevent apoptosis and lead to the production of cytokines such as IL-4 and IL-13.

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