- Phare
- Validé par KD/KO
Anticorps Monoclonal anti-IDH2
IDH2 Monoclonal Antibody for WB, FC (Intra), Indirect ELISA
Hôte / Isotype
Mouse / IgG1
Réactivité testée
Humain
Applications
WB, FC (Intra), Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
1F10A10
N° de cat : 66918-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
66918-1-PBS cible IDH2 dans les applications de WB, FC (Intra), Indirect ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain | 
| Hôte / Isotype | Mouse / IgG1 | 
| Clonalité | Monoclonal | 
| Type | Anticorps | 
| Immunogène | IDH2 Protéine recombinante Ag8950 | 
| Nom complet | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 
| Masse moléculaire calculée | 452 aa, 51 kDa | 
| Poids moléculaire observé | 41-47 kDa | 
| Numéro d’acquisition GenBank | BC009244 | 
| Symbole du gène | IDH2 | 
| Identification du gène (NCBI) | 3418 | 
| Conjugaison | Non conjugué | 
| Forme | Liquide | 
| Méthode de purification | Purification par protéine G | 
| Tampon de stockage | PBS only | 
| Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. | 
Informations générales
IDH2, also named as IDP and ICD-M, belongs to the isocitrate and isopropylmalate dehydrogenases family. It plays a role in intermediary metabolism and energy production. IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. It may tightly associate or interact with the pyruvate dehydrogenase complex. IDH1 and IDH2 mutations could also contribute to tumorigenesis and cancer progression through increased mutagenesis. IDH2 has 2 isoforms with the MW of 51 kDa and 45 kDa, and the mature form is about 47 kDa and 41 kDa with the N-terminal transit peptide cleaved.









