Anticorps Recombinant de lapin anti-IFNGR1/CD119

IFNGR1/CD119 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242632A8

N° de cat : 98343-1-RR

Synonymes

IFNGR1, IFN-gamma receptor 1, IFN-gamma R1, IFN gamma receptor 1, IFN gamma R1

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocytes using 98343-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IFNGR1/CD119 Rabbit RecAb (98343-1-RR, Clone: 242632A8) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

• 

  FC experiment of human peripheral blood leukocytes using 98343-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IFNGR1/CD119 Rabbit RecAb (98343-1-RR, Clone: 242632A8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98343-1-RR cible IFNGR1/CD119 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interferon gamma receptor 1
• Masse moléculaire calculée: 54 kDa
• Numéro d’acquisition GenBank: NM_000416.3
• Symbole du gène: IFNGR1
• Identification du gène (NCBI): 3459
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)

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