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Anticorps Recombinant de lapin anti-IGF1R/CD221

IGF1R/CD221 Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

240801A3

N° de cat : 83873-6-PBS

Synonymes

IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using IGF1R/CD221 Recombinant antibody (83873-6-RR)

    WB analysis using 83873-6-RR (same clone as 83873-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83873-6-RR (IGF1R antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83873-6-PBS in a different storage buffer formulation.

Informations sur le produit

83873-6-PBS cible IGF1R/CD221 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Peptide
Nom complet IGF I receptor
Masse moléculaire calculée 155 kDa
Poids moléculaire observé100 kDa
Numéro d’acquisition GenBankNM_000875
Symbole du gène IGF1R
Identification du gène (NCBI) 3480
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220 kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (~130 kDa) and two beta subunits (~100-120 kDa) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.

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