Anticorps Recombinant de lapin anti-IGF1R/CD221

IGF1R/CD221 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241679A6

N° de cat : 98144-1-RR

Synonymes

IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR

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Galerie de données de validation

• 

  FC experiment of human peripheral blood granulocytes using 98144-1-RR

  1x10^6 human peripheral blood granulocytes were surface stained with 0.25 ug Anti-Human IGF1R/CD221 Rabbit Recombinant Antibody (98144-1-RR, Clone: 241679A6)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98144-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98144-1-RR against Human IGF1R/CD221 were performed. The affinity constant is 83.6 pM.

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Applications testées

• Résultats positifs en cytométrie: granylocytes de sang périphérique humain,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98144-1-RR cible IGF1R/CD221 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: IGF I receptor
• Masse moléculaire calculée: 1367 aa, 155 kDa
• Numéro d’acquisition GenBank: BC113612
• Symbole du gène: IGF1R
• Identification du gène (NCBI): 3480
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220 kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (~130 kDa) and two beta subunits (~100-120 kDa) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.

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