Anticorps Recombinant de lapin anti-IGF1R/CD221

IGF1R/CD221 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

PE Fluorescent Dye

CloneNo.

241679A6

N° de cat : PE-FcA98144

Synonymes

IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR

---

Galerie de données de validation

• 

  FC experiment of human peripheral blood leukocyte using PE-FcA98144

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul PE Anti-Human IGF1R/CD221 Rabbit RecAb (PE-FcA98144, Clone:241679A6) or PE Rabbit IgG Isotype Control RecAb (PE-FcA98136, Clone: 240953C9). Cells were not fixed.

• 

  FC experiment of human peripheral blood leukocyte using PE-FcA98144

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul PE Anti-Human IGF1R/CD221 Rabbit RecAb (PE-FcA98144, Clone:241679A6) (red) or PE Rabbit IgG Isotype Control RecAb (PE-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

---

Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

PE-FcA98144 cible IGF1R/CD221 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: IGF I receptor
• Masse moléculaire calculée: 1367 aa, 155 kDa
• Numéro d’acquisition GenBank: BC113612
• Symbole du gène: IGF1R
• Identification du gène (NCBI): 3480
• Conjugaison: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220 kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.

{{ptg:RelatedPrimaryAntibodies}}