Anticorps Recombinant de lapin anti-IL-1 beta

IL-1 beta Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC (Intra)

Conjugaison

Non conjugué

CloneNo.

241364B3

N° de cat : 98179-1-PBS

Synonymes

IL 1beta, Il1b, IL-1,IL1, IL-1 beta,IL 1 beta,IL1beta, Il 1b

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Galerie de données de validation

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  FC experiment of mouse peritoneal macrophages using 98179-1-RR (same clone as 98179-1-PBS)

  1x10^6 untreated or LPS and Brefeldin A treated mouse peritoneal macrophages were intracellularly stained with 0.25 ug Anti-Mouse IL-1 beta Rabbit Recombinant Antibody (98179-1-RR, Clone: 241364B3) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with APC anti-Mouse CD11b. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98179-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98179-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98179-1-RR against Mouse IL-1 beta/IL-1F2 were performed. The affinity constant is 32.5 pM.

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Informations sur le produit

98179-1-PBS cible IL-1 beta dans les applications de FC (Intra) et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 1 beta
• Masse moléculaire calculée: 31kDa
• Numéro d’acquisition GenBank: NM_008361.4
• Symbole du gène: IL-1 beta
• Identification du gène (NCBI): 16176
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. Interleukin 1β(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in mediating both acute and chronic inflammation. IL-1β is known to be involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. IL-1β is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions (PMID: 8630372; PMID: 12401481; PMID: 23704929; PMID: 24618930).

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