Anticorps Polyclonal de lapin anti-IL-10RA

IL-10RA Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 13356-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 13356-1-AP (same clone as 13356-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 13356-1-AP (IL-10RA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13356-1-PBS in a different storage buffer formulation.

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  WB analysis of human liver using 13356-1-AP (same clone as 13356-1-PBS)

  human liver tissue were subjected to SDS PAGE followed by western blot with 13356-1-AP (IL10RA antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13356-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human heart using 13356-1-AP (same clone as 13356-1-PBS)

  human heart tissue were subjected to SDS PAGE followed by western blot with 13356-1-AP (IL10RA antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13356-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human placenta using 13356-1-AP (same clone as 13356-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 13356-1-AP (IL10RA antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13356-1-PBS in a different storage buffer formulation.

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Informations sur le produit

13356-1-PBS cible IL-10RA dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: IL-10RA Protéine recombinante Ag4156
• Nom complet: interleukin 10 receptor, alpha
• Masse moléculaire calculée: 578 aa, 63 kDa
• Poids moléculaire observé: 70-72 kDa, 90-95 kDa
• Numéro d’acquisition GenBank: BC028082
• Symbole du gène: IL-10RA
• Identification du gène (NCBI): 3587
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB) (PMID: 22236434). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RA, also known as IL-10R1 or CD210, is expressed on most hematopoietic cells at a basal level but is upregulated by various cells upon activation (PMID: 24507158). IL-10RA serves as the ligand-binding subunit of the receptor complex. Upon binding of IL-10 to the IL-10R complex, the kinases JAK1 and TYK2 are activated and catalyze the phosphorylation of IL-10RA at specific intracellular tyrosine residues, leading to the recruitment and subsequent phosphorylation of STAT3 (PMID: 11244051; 10433356).

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