Anticorps Monoclonal anti-IL-12/IL-23 p40

IL-12/IL-23 p40 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, porc

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

4B2A8

N° de cat : 66288-1-PBS

Synonymes

IL12B, IL 12B, IL 12 subunit p40, IL 12 P40, Cytotoxic lymphocyte maturation factor 40 kDa subunit

---

Galerie de données de validation

• 

  WB analysis of human liver using 66288-1-Ig (same clone as 66288-1-PBS)

  human liver tissue were subjected to SDS PAGE followed by western blot with 66288-1-Ig (IL12B Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66288-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

66288-1-PBS cible IL-12/IL-23 p40 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc

• Réactivité: Humain, porc
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: IL-12/IL-23 p40 Protéine recombinante Ag21429
• Nom complet: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
• Masse moléculaire calculée: 328 aa, 37 kDa
• Poids moléculaire observé: 37 kDa
• Numéro d’acquisition GenBank: BC067498
• Symbole du gène: IL12B
• Identification du gène (NCBI): 3593
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

{{ptg:RelatedPrimaryAntibodies}}