Anticorps Recombinant de lapin anti-IL-12RB1/CD212

IL-12RB1/CD212 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241661H1

N° de cat : 98149-1-RR

Synonymes

IL12RB1, IL-12 receptor beta component, IL 12RB1, IL 12R subunit beta 1, IL 12R beta 1

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Galerie de données de validation

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  FC experiment of human PBMCs using 98149-1-RR

  1x10^6 anti-CD3/CD28 treated human PBMCs were surface stained with 0.25 ug Anti-Human IL-12RB1/CD212 Rabbit Recombinant Antibody (98149-1-RR, Clone: 241661H1) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human IL-12RB1/CD212 Rabbit Recombinant Antibody (98149-1-RR, Clone: 241661H1) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98149-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98149-1-RR against Human IL-12RB1/CD212 were performed. The affinity constant is 2.2 nM.

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Applications testées

• Résultats positifs en cytométrie: anti-CD3/CD28 treated human PBMCs

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98149-1-RR cible IL-12RB1/CD212 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 12 receptor, beta 1
• Masse moléculaire calculée: 662 aa, 73 kDa
• Numéro d’acquisition GenBank: BC029121
• Symbole du gène: IL12RB1
• Identification du gène (NCBI): 3594
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Interleukin-12 receptor subunit beta-1 (IL-12RB1), also named as CD212, is a 662 amino acid protein, which contains 5 fibronectin type-III domains and belongs to the type I cytokine receptor family. IL-12RB1 localizes in the membrane and functions as an interleukin receptor which binds IL-12 with low affinity and is involved in IL-12 transduction. Associated with IL-12RB2 it forms a functional, high affinity receptor for IL-12. It can also associate with IL23R to form the interleukin-23 receptor which functions in IL-23 signal transduction probably through activation of the Jak-Stat signaling cascade.

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