Anticorps Recombinant de lapin anti-IL-13RA2

IL-13RA2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242742F11

N° de cat : 85631-1-PBS

Synonymes

CD213a2, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, Il13ra2, IL-13R-alpha-2

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Galerie de données de validation

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  WB analysis using 85631-1-RR (same clone as 85631-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85631-1-RR (IL-13RA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85631-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85631-1-PBS cible IL-13RA2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-13RA2 Protéine recombinante Eg3118
• Nom complet: interleukin 13 receptor, alpha 2
• Masse moléculaire calculée: 44 kDa
• Poids moléculaire observé: 65 kDa
• Numéro d’acquisition GenBank: NM_008356.4
• Symbole du gène: Il13ra2
• Identification du gène (NCBI): 16165
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IL13RA2, also named as IL13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875).

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