Anticorps Monoclonal anti-IL-16

IL-16 Monoclonal Antibody for WB, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1C4C7

N° de cat : 66145-1-PBS

Synonymes

IL16, 1C4C7, IL 16, interleukin-16, prIL 16

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Galerie de données de validation

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  WB analysis of Recombinant protein using 66145-1-Ig (same clone as 66145-1-PBS)

  Recombinant protein were subjected to SDS PAGE followed by western blot with 66145-1-Ig (IL-16 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66145-1-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP51113-1

  Cytometric bead array standard curve of MP51113-1, IL-16 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 66145-1-PBS. Detection antibody: 66145-2-PBS. Standard:Ag16466. Range: 3.125-200 ng/mL.

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  Affinity and Kinetic Characterization of 66145-1-Ig

  Biolayer interferometry (BLl) kinetic assay of 66145-1-Ig against Human IL-16 was performed. The affinity constant is below 1 pM.

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Informations sur le produit

66145-1-PBS cible IL-16 dans les applications de WB, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: IL-16 Protéine recombinante Ag16466
• Nom complet: interleukin 16 (lymphocyte chemoattractant factor)
• Masse moléculaire calculée: 130 aa, 15 kDa
• Poids moléculaire observé: 37 kDa
• Numéro d’acquisition GenBank: BC040272
• Symbole du gène: IL-16
• Identification du gène (NCBI): 3603
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. It is mainly produced by T lymphocytes but also by other immune cells, neuronal cells, fibroblasts and epithelial cells. The signaling process of this cytokine is mediated by CD4. IL-16 induces chemotaxis of CD4+ cells such as lymphocytes, eosinophils, and dendritic cells by ligating CD4 directly at a site distinct from other ligands. Among its multiple functions, IL-16 is a T cell chemoattractant involved in T helper cell inflammatory responses and the regulation of both T cell growth, and responsiveness to regulatory cytokines. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control.

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