Anticorps Recombinant de lapin anti-IL-17A

IL-17A Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250413G7

N° de cat : 98564-1-PBS

Synonymes

Il17a, Interleukin 17A

---

Galerie de données de validation

• 

  FC experiment of Transfected HEK-293T using 98564-1-RR (same clone as 98564-1-PBS)

  1x10^6 HEK-293T cells (left) and IL-17A transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Rat IL-17A Rabbit RecAb (98564-1-RR, Clone: 250413G7) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98564-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98564-1-RR (same clone as 98564-1-PBS)

  1x10^6 HEK-293Tcells (left) and IL-17A transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Rat IL-17A Rabbit RecAb (98564-1-RR, Clone: 250413G7) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98564-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

98564-1-PBS cible IL-17A dans les applications de FC et montre une réactivité avec des échantillons rat

• Réactivité: rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-17A Protéine recombinante Eg3339
• Nom complet: similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
• Masse moléculaire calculée: 17kDa
• Symbole du gène: LOC301289
• Identification du gène (NCBI): 301289
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

IL-17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

{{ptg:RelatedPrimaryAntibodies}}