Anticorps Polyclonal de lapin anti-IL-17B

IL-17B Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24495-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 24495-1-AP (same clone as 24495-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24495-1-AP (IL-17B antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24495-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24495-1-PBS cible IL-17B dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: IL-17B Protéine recombinante Ag21453
• Nom complet: interleukin 17B
• Masse moléculaire calculée: 180 aa, 20 kDa
• Poids moléculaire observé: 24 kDa
• Numéro d’acquisition GenBank: BC113925
• Symbole du gène: IL-17B
• Identification du gène (NCBI): 27190
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The interleukin (IL)-17 superfamily, a relatively new family of cytokines, consists of six ligands (from IL-17A to IL-17F), which bind to five receptor subtypes (from IL-17RA to IL-17RE) and induce downstream signaling. IL-17B was originally described as increased during intestinal inflammation. Moreover, it stimulates TNF-α and IL-1β production by the human monocytic leukemia THP-1 cells and promotes neutrophil migration upon intraperitoneal administration, suggesting a pro-inflammatory role. More recent findings strongly suggest a role for the IL-17B/IL-17RB pathway in tumorigenesis.

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