Anticorps Recombinant de lapin anti-IL-17RB

IL-17RB Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242967D1

N° de cat : 98455-2-PBS

Synonymes

Evi27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, Il17br

---

Galerie de données de validation

• 

  FC experiment of Transfected HEK-293T using 98455-2-RR (same clone as 98455-2-PBS)

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone: 242967D1) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98455-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98455-2-RR (same clone as 98455-2-PBS)

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone:242967D1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98455-2-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98455-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98455-2-RR against Mouse IL-17RB were performed. The affinity constant is 0.697 nM.

---

Informations sur le produit

98455-2-PBS cible IL-17RB dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-17RB Protéine recombinante Eg2798
• Nom complet: interleukin 17 receptor B
• Masse moléculaire calculée: 56 kDa
• Numéro d’acquisition GenBank: NM_019583.3
• Symbole du gène: Il17rb
• Identification du gène (NCBI): 50905
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

IL-17RB is a transmembrane protein that belongs to the IL-17 receptor family. IL-17RB has a SEFIR cytoplasmic domain implicated in homotypic dimerization and recruitment of signaling proteins (shared with IL-17RA) and a TRAF6-binding domain (not found in IL-17RA). IL-17RB is expressed in various endocrine tissues and epithelial cells in different organs such as kidney, liver, and mucosal tissues. The IL-17B/IL-17RB pathway is considered as a signaling cascade that promotes cancer cell survival, proliferation and migration. The pro-tumor functions associated with the IL 17B/IL-17RB pathway are diverse and complex because they involve mechanisms that act directly on tumor cells, and also indirect mechanisms that lead to tumor microenvironment remodeling.

{{ptg:RelatedPrimaryAntibodies}}