Anticorps Recombinant de lapin anti-IL-17RB

IL-17RB Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242967D1

N° de cat : 98455-2-RR

Synonymes

Evi27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, Il17br

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98455-2-RR

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone: 242967D1) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of Transfected HEK-293T using 98455-2-RR

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone:242967D1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98455-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98455-2-RR against Mouse IL-17RB were performed. The affinity constant is 0.697 nM.

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Applications testées

• Résultats positifs en cytométrie: Transfected HEK-293T cells,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98455-2-RR cible IL-17RB dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-17RB Protéine recombinante Eg2798
• Nom complet: interleukin 17 receptor B
• Masse moléculaire calculée: 56 kDa
• Numéro d’acquisition GenBank: NM_019583.3
• Symbole du gène: Il17rb
• Identification du gène (NCBI): 50905
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

IL-17RB is a transmembrane protein that belongs to the IL-17 receptor family. IL-17RB has a SEFIR cytoplasmic domain implicated in homotypic dimerization and recruitment of signaling proteins (shared with IL-17RA) and a TRAF6-binding domain (not found in IL-17RA). IL-17RB is expressed in various endocrine tissues and epithelial cells in different organs such as kidney, liver, and mucosal tissues. The IL-17B/IL-17RB pathway is considered as a signaling cascade that promotes cancer cell survival, proliferation and migration. The pro-tumor functions associated with the IL 17B/IL-17RB pathway are diverse and complex because they involve mechanisms that act directly on tumor cells, and also indirect mechanisms that lead to tumor microenvironment remodeling.

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