Anticorps Recombinant de lapin anti-IL-18R1/CD218a

IL-18R1/CD218a Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241673D3

N° de cat : 98150-2-PBS

Synonymes

IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6

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Galerie de données de validation

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  FC experiment of human PBMCs using 98150-2-RR (same clone as 98150-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone:241673D3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98150-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98150-2-RR (same clone as 98150-2-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone: 241673D3) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9)(blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98150-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98150-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98150-2-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.915 nM.

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Informations sur le produit

98150-2-PBS cible IL-18R1/CD218a dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 18 receptor 1
• Masse moléculaire calculée: 541 aa, 62 kDa
• Numéro d’acquisition GenBank: BC093975
• Symbole du gène: IL18R1
• Identification du gène (NCBI): 8809
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).

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