Anticorps Recombinant de lapin anti-IL-18R1/CD218a

IL-18R1/CD218a Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241673D3

N° de cat : 98150-2-RR

Synonymes

IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6

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Galerie de données de validation

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  FC experiment of human PBMCs using 98150-2-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone:241673D3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

• 

  FC experiment of human PBMCs using 98150-2-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone: 241673D3) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9)(blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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  Affinity and Kinetic Characterization of 98150-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98150-2-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.915 nM.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98150-2-RR cible IL-18R1/CD218a dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 18 receptor 1
• Masse moléculaire calculée: 541 aa, 62 kDa
• Numéro d’acquisition GenBank: BC093975
• Symbole du gène: IL18R1
• Identification du gène (NCBI): 8809
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).

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