Anticorps Recombinant de lapin anti-IL-18R1/CD218a

IL-18R1/CD218a Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

FITC Plus Fluorescent Dye

CloneNo.

241673D3

N° de cat : FITC-98150

Synonymes

IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocytes using FITC-98150

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul FITC Plus Anti-Human IL-18R1/CD218a Rabbit RecAb (FITC-98150, Clone: 241673D3) or FITC Plus Rabbit IgG Isotype Control RecAb (FITC-98136, Clone: 240953C9). Cells were co-stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56 (B-A19) (CL647-65264, Clone: B-A19). Cells were not fixed.

• 

  FC experiment of human peripheral blood leukocytes using FITC-98150

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul FITC Plus Anti-Human IL-18R1/CD218a Rabbit RecAb (FITC-98150, Clone: 241673D3) (red) or FITC Plus Rabbit IgG Isotype Control RecAb (FITC-98136, Clone: 240953C9) (blue). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes,

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

FITC-98150 cible IL-18R1/CD218a dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 18 receptor 1
• Masse moléculaire calculée: 541 aa, 62 kDa
• Numéro d’acquisition GenBank: BC093975
• Symbole du gène: IL18R1
• Identification du gène (NCBI): 8809
• Conjugaison: FITC Plus Fluorescent Dye
• Excitation/Emission maxima wavelengths: 495 nm / 524 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).

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