Anticorps Monoclonal anti-IL-19

IL-19 Monoclonal Antibody for IF-P

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

IF-P

Conjugaison

CoraLite®594 Fluorescent Dye

CloneNo.

8H10H8

N° de cat : CL594-60278

Synonymes

IL 10C, IL 19, IL19, IL-19, interleukin 19, MDA1, NG.1, ZMDA1

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Galerie de données de validation

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  IF Staining of human tonsillitis using CL594-60278

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 IL-19 antibody (CL594-60278, Clone: 8H10H8 ) at dilution of 1:200.

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  IF Staining of human tonsillitis using CL594-60278

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 IL-19 antibody (CL594-60278, Clone: 8H10H8 ) at dilution of 1:200.

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Applications testées

• Résultats positifs en IF-P: tissu d'amygdalite humain,

Dilution recommandée

• Immunofluorescence (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

CL594-60278 cible IL-19 dans les applications de IF-P et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: IL-19 Protéine recombinante Ag18887
• Nom complet: interleukin 19
• Masse moléculaire calculée: 177 aa, 20 kDa
• Numéro d’acquisition GenBank: BC153127
• Symbole du gène: IL-19
• Identification du gène (NCBI): 29949
• Conjugaison: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Conditions de stockage: Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.

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