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Anticorps Recombinant de lapin anti-IL-1RA

IL-1RA Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241879B3

N° de cat : 84532-4-PBS

Synonymes

IL 1ra, IL1RN, 241879B3, ICIL-1RA, IL 1RN

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using IL-1RA Recombinant antibody (84532-4-RR)

    WB analysis using 84532-4-RR (same clone as 84532-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84532-4-RR (IL-1RA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84532-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84532-4-RR

    Affinity and Kinetic Characterization of 84532-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84532-4-RR against Human IL-1RA were performed. The affinity constant is 0.302 nM.

Informations sur le produit

84532-4-PBS cible IL-1RA dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène IL-1RA Protéine recombinante Ag1277
Nom complet interleukin 1 receptor antagonist
Masse moléculaire calculée 20 kDa
Poids moléculaire observé16-18 kDa
Numéro d’acquisition GenBankBC009745
Symbole du gène IL-1RA
Identification du gène (NCBI) 3557
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-1 receptor antagonist (IL-1RA) is a critical member of the IL-1 family of cytokines, which plays a significant role in modulating inflammatory responses. IL-1RA exists in two main forms: a secreted form (sIL-1Ra) and an intracellular form (icIL-1Ra). The secreted form is produced by various cells including monocytes, macrophages, neutrophils, and other cells, while the intracellular form is found in keratinocytes and other epithelial cells, as well as in monocytes and fibroblasts. IL-1RA is important in host defense against endotoxin-induced injury and is produced in numerous experimental animal models of disease, as well as in human autoimmune and chronic inflammatory diseases. It acts as an anti-inflammatory agent by maintaining the balance between pro-inflammatory IL-1α/β and its own anti-inflammatory effects.

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