Anticorps Recombinant de lapin anti-IL-22

IL-22 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250428B5

N° de cat : 82766-15-PBS

Synonymes

IL22, Cytokine Zcyto18, IL 21, IL 22, IL D110

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Galerie de données de validation

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  WB analysis using 82766-15-RR (same clone as 82766-15-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82766-15-PBS in a different storage buffer formulation.

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  WB analysis of Recombinant protein using 82766-15-RR (same clone as 82766-15-PBS)

  Recombinant protein were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82766-15-PBS in a different storage buffer formulation.

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Informations sur le produit

82766-15-PBS cible IL-22 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-22 Protéine recombinante HZ-1325
• Nom complet: interleukin 22
• Poids moléculaire observé: 20 kDa
• Numéro d’acquisition GenBank: BC066263
• Symbole du gène: IL-22
• Identification du gène (NCBI): 50616
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, primarily produced by immune cells such as group 3 innate lymphoid cells (ILC3s), Th17 cells, Th22 cells, and γδ T cells (PMID: 25706098). Its unique feature lies in targeting non-immune epithelial and stromal cells, which exclusively express the heterodimeric IL-22 receptor (IL-22R1 and IL-10R2). IL-22 plays a dual role in immunity and tissue homeostasis: it promotes epithelial cell proliferation, regeneration, and barrier integrity through the upregulation of antimicrobial peptides (e.g., defensins) and mucin production, thereby enhancing defense against extracellular pathogens. However, IL-22 can also drive pathological inflammation in autoimmune and chronic inflammatory diseases (e.g., psoriasis, colitis) when dysregulated. This functional dichotomy highlights its context-dependent nature as both a protective mediator and a pathogenic effector (PMID: 20498020).

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