Anticorps Recombinant de lapin anti-IL-23 p19

IL-23 p19 Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC (Intra)

Conjugaison

Non conjugué

CloneNo.

242139G12

N° de cat : 98392-1-PBS

Synonymes

IL-23 subunit alpha, Il23a, IL-23A, IL-23-A, IL23P19

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98392-1-RR (same clone as 98392-1-PBS)

  1x10^6 HEK-293T cells(left) and IL23A -transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse IL23A Rabbit RecAb (98392-1-RR, Clone:242139G12) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98392-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98392-1-RR (same clone as 98392-1-PBS)

  1x10^6 HEK-293T cells(left) and IL23A -transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse IL23A Rabbit RecAb (98392-1-RR, Clone:242139G12)(red), or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98392-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98392-1-PBS cible IL-23 p19 dans les applications de FC (Intra) et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-23 p19 Protéine recombinante Eg1634
• Nom complet: interleukin 23, alpha subunit p19
• Masse moléculaire calculée: 22 kDa
• Numéro d’acquisition GenBank: NM_031252.2
• Symbole du gène: Il23a
• Identification du gène (NCBI): 83430
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

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