Anticorps Recombinant de lapin anti-IL-5
IL-5 Recombinant Antibody for FC (Intra)
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain
Applications
FC (Intra)
Conjugaison
Non conjugué
CloneNo.
240915D12
N° de cat : 98178-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
98178-1-PBS cible IL-5 dans les applications de FC (Intra) et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Recombinant |
| Type | Anticorps |
| Immunogène | Protéine recombinante |
| Nom complet | interleukin 5 (colony-stimulating factor, eosinophil) |
| Masse moléculaire calculée | 134 aa, 15 kDa |
| Numéro d’acquisition GenBank | BC066282 |
| Symbole du gène | IL5 |
| Identification du gène (NCBI) | 3567 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Protein A purfication |
| Tampon de stockage | PBS only |
| Conditions de stockage | Store at -80°C. |
Informations générales
IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity. (PMID: 21986312, 22174445, 19819937, 16895557)



