Anticorps Polyclonal de lapin anti-IL-5RA/CD125

IL-5RA/CD125 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12655-1-PBS

Synonymes

IL5RA, CD125, HSIL5R3, IL 5 receptor subunit alpha, IL 5R alpha

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Galerie de données de validation

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  WB analysis of human peripheral blood platelets using 12655-1-AP (same clone as 12655-1-PBS)

  human peripheral blood platelets were subjected to SDS PAGE followed by western blot with 12655-1-AP (IL-5RA antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12655-1-PBS in a different storage buffer formulation.

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  WB analysis of Jurkat using 12655-1-AP (same clone as 12655-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 12655-1-AP (IL5RA antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12655-1-PBS in a different storage buffer formulation.

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Informations sur le produit

12655-1-PBS cible IL-5RA/CD125 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: IL-5RA/CD125 Protéine recombinante Ag3358
• Nom complet: interleukin 5 receptor, alpha
• Masse moléculaire calculée: 48 kDa, 38 kDa
• Poids moléculaire observé: 70-75 kDa, 43 kDa
• Numéro d’acquisition GenBank: BC027599
• Symbole du gène: IL-5RA/CD125
• Identification du gène (NCBI): 3568
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-5 receptor subunit alpha (IL-5RA), also known as CD125, is a type I transmembrane protein that belongs to the type I cytokine receptor family. IL-5RA is a critical component of the high-affinity IL-5 receptor complex, IL-5R, which consists of the alpha chain (IL-5RA) that specifically binds to IL-5 and the common beta chain (CD131) shared with receptors for IL-3 and GM-CSF (PMID: 1833065; 7872157). IL-5/IL-5RA signaling axis is crucial for the differentiation, proliferation, recruitment, and activation of eosinophils, and is also involved in pathological eosinophilia (PMID: 34638583).

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