Anticorps Recombinant de lapin anti-IL-5RA/CD125

IL-5RA/CD125 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242234C8

N° de cat : 98338-1-PBS

Synonymes

IL5RA, CD125, HSIL5R3, IL 5 receptor subunit alpha, IL 5R alpha

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocyte using 98338-1-RR (same clone as 98338-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-5RA/CD125 Rabbit RecAb (98338-1-RR, Clone:242234C8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human Siglec-8 Rabbit Recombinant Antibody (CL647-98177, Clone: 241275A5). CD11b+ cells were pre-gated for analysis. Cells were not fixed. This data was developed using the same antibody clone with 98338-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98338-1-PBS cible IL-5RA/CD125 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-5RA/CD125 Protéine recombinante Eg1665
• Nom complet: interleukin 5 receptor, alpha
• Masse moléculaire calculée: 48 kDa
• Numéro d’acquisition GenBank: NM_175726.4
• Symbole du gène: IL-5RA/CD125
• Identification du gène (NCBI): 3568
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Interleukin-5 receptor subunit alpha (IL-5RA), also known as CD125, is a type I transmembrane protein that belongs to the type I cytokine receptor family. IL-5RA is a critical component of the high-affinity IL-5 receptor complex, IL-5R, which consists of the alpha chain (IL-5RA) that specifically binds to IL-5 and the common beta chain (CD131) shared with receptors for IL-3 and GM-CSF (PMID: 1833065; 7872157). IL-5/IL-5RA signaling axis is crucial for the differentiation, proliferation, recruitment, and activation of eosinophils, and is also involved in pathological eosinophilia (PMID: 34638583).

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