Anticorps Recombinant de lapin anti-IL-18R1/CD218a

IL-18R1/CD218a Recombinant Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241673G6

N° de cat : 84390-5-PBS

Synonymes

IL18R1, IL 18R1, IL 18R 1, EC:3.2.2.6, CD218a

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Galerie de données de validation

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  WB analysis of NK-92 using 84390-5-RR (same clone as 84390-5-PBS)

  NK-92 cells were subjected to SDS PAGE followed by western blot with 84390-5-RR (IL18R1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84390-5-PBS in a different storage buffer formulation.

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  IF Staining of NK-92 using 84390-5-RR (same clone as 84390-5-PBS)

  Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using IL-18R1/CD218a antibody (84390-5-RR, Clone: 241673G6 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84390-5-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84390-5-RR

  Biolayer interferometry (BLl) kinetic assays of 84390-5-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.948 nM.

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Informations sur le produit

84390-5-PBS cible IL-18R1/CD218a dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 18 receptor 1
• Masse moléculaire calculée: 541 aa, 62 kDa
• Poids moléculaire observé: 60-75 kDa
• Numéro d’acquisition GenBank: BC093975
• Symbole du gène: IL18R1
• Identification du gène (NCBI): 8809
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).

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