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Anticorps Recombinant de lapin anti-IL-6

IL-6 Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

240670B3

N° de cat : 83747-7-PBS

Synonymes

IL6, Interferon beta-2, IL 6, IFN-beta-2, B-cell stimulatory factor 2

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of HUVEC cells using IL-6 Recombinant antibody (83747-7-RR)

    WB analysis of HUVEC using 83747-7-RR (same clone as 83747-7-PBS)

    LPS and Brefeldin A treated HUVEC cells were subjected to SDS PAGE followed by western blot with 83747-7-RR (IL-6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83747-7-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83747-7-RR

    Affinity and Kinetic Characterization of 83747-7-RR

    Biolayer interferometry (BLl) kinetic assays of 83747-7-RR against Human IL-6 were performed. The affinity constant is 1.72 nM.

Informations sur le produit

83747-7-PBS cible IL-6 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Protéine recombinante
Nom complet interleukin 6 (interferon, beta 2)
Masse moléculaire calculée 212 aa, 24 kDa
Poids moléculaire observé20 kDa
Numéro d’acquisition GenBankBC015511
Symbole du gène IL6
Identification du gène (NCBI) 3569
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

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