Anticorps Recombinant de lapin anti-INPP5A

INPP5A Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250584C3

N° de cat : 86001-1-PBS

Synonymes

43 kDa inositol polyphosphate 5-phosphatase, 5PTASE, EC:3.1.3.56, Inositol polyphosphate-5-phosphatase A, Type I inositol 1,4,5-trisphosphate 5-phosphatase

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Galerie de données de validation

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  WB analysis using 86001-1-RR (same clone as 86001-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86001-1-RR (INPP5A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86001-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86001-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86001-1-RR against Human INPP5A were performed. The affinity constant is below 1 pM.

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Informations sur le produit

86001-1-PBS cible INPP5A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: INPP5A Protéine recombinante Ag16380
• Nom complet: inositol polyphosphate-5-phosphatase, 40kDa
• Masse moléculaire calculée: 412 aa, 48 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC096280
• Symbole du gène: INPP5A
• Identification du gène (NCBI): 3632
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

INPP5A (Inositol Polyphosphate-5-Phosphatase A) is a membrane-bound type I inositol 1,4,5-trisphosphate 5-phosphatase that is involved in the mobilization of intracellular calcium ions and the regulation of cellular responses to stimuli. It terminates calcium signaling by hydrolyzing inositol 1,4,5-trisphosphate (InsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). INPP5A plays important roles in various cellular processes, including cell proliferation, apoptosis, vesicular transport, and insulin signaling. Additionally, INPP5A is crucial for the survival of cerebellar Purkinje cells. In certain cancers, such as cutaneous squamous cell carcinoma (cSCC) and esophageal squamous cell carcinoma (ESCC), the expression levels of INPP5A are closely related to disease progression and prognosis.

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