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Anticorps Recombinant de lapin anti-INSIG1

INSIG1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241353C7

N° de cat : 84352-1-PBS

Synonymes

241353C7, CL 6, INSIG 1, INSIG-1, insulin induced gene 1

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using INSIG1 Recombinant antibody (84352-1-RR)

    WB analysis using 84352-1-RR (same clone as 84352-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84352-1-RR (INSIG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84352-1-PBS in a different storage buffer formulation.

Informations sur le produit

84352-1-PBS cible INSIG1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Peptide
Nom complet insulin induced gene 1
Masse moléculaire calculée 30 kDa
Poids moléculaire observé35 kDa
Numéro d’acquisition GenBankNM_005542
Symbole du gène INSIG1
Identification du gène (NCBI) 3638
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Insulin-induced genes (INSIGs), which consist of two isoforms (INSIG1 and INSIG2), are representative endoplasmic reticulum (ER)-resident oxysterol-binding proteins (OSBPs). INSIG1 is part of negative regulatory feedback, acting as a brake on SREBP transcriptional function (PMID: 23919961). INSIG1 also has a secondary function mediating sterolaccelerated proteolytic degradation of HMG CoA reductase, thus impacting the mevalonate pathway. Suppression of INSIG1 function promotes hepatic lipid remodelling and restrains NASH (non-alcoholic steatohepatitis) progression (PMID: 33722690).

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