Anticorps Polyclonal de lapin anti-INSM2

INSM2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33151-1-PBS

Synonymes

IA6, INSM Transcriptional Repressor 2 , Insulinoma-associated protein 2, Nbla106, Zinc finger protein IA-6

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Galerie de données de validation

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  WB analysis using 33151-1-AP (same clone as 33151-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33151-1-AP (INSM2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33151-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33151-1-PBS cible INSM2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: INSM2 Protéine recombinante Ag38945
• Nom complet: insulinoma-associated 2
• Masse moléculaire calculée: 59kDa，566aa
• Poids moléculaire observé: 68 kDa
• Numéro d’acquisition GenBank: NM_032594.3
• Symbole du gène: INSM2
• Identification du gène (NCBI): 84684
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

INSM2 (Insulinoma-associated protein 2) is a zinc-finger protein belonging to the transcription factor family and has transcriptional repressive functions. It may exert growth-inhibitory or tumor-suppressive effects in hepatocytes and certain neurons. The primary function of INSM2 involves the regulation of gene expression, particularly the repression of insulin gene expression in non-pancreatic cells. Additionally, INSM2 is upregulated in neuroblastoma and is associated with poor prognosis. It promotes tumor development by affecting lipid metabolism through the regulation of the mTOR signaling pathway.

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