Anticorps Recombinant de lapin anti-INVS

INVS Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

250038E2

N° de cat : 85768-2-RR

Synonymes

INV, Inversin, KIAA0573, Nephrocystin 2, Nephrocystin-2

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Galerie de données de validation

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  WB analysis using 85768-2-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85768-2-RR (INVS antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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  Affinity and Kinetic Characterization of 85768-2-RR

  Biolayer interferometry (BLl) kinetic assays of 85768-2-RR against Human INVS were performed. The affinity constant is 6.36 nM.

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Applications testées

• Résultats positifs en WB: cellules Jurkat, cellules K-562, cellules SH-SY5Y

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

85768-2-RR cible INVS dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: INVS Protéine recombinante Ag0934
• Nom complet: inversin
• Masse moléculaire calculée: 118 kDa, 100 kDa
• Poids moléculaire observé: 100 kDa
• Numéro d’acquisition GenBank: BC006370
• Symbole du gène: INVS
• Identification du gène (NCBI): 27130
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

INVS, short for inversin, plays a role in primary cilia function and involvement in the cell cycle. It is required for normal renal development and establishment of the left-right axis. INVS may be involved in Wnt signaling pathways by acting as a molecular switch between different them. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling.

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