Anticorps Polyclonal de lapin anti-IQCG

IQCG Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33459-1-PBS

Synonymes

DRC9, Dynein regulatory complex protein 9, IQ domain-containing protein G

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Galerie de données de validation

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  WB analysis using 33459-1-AP (same clone as 33459-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33459-1-AP (IQCG antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33459-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33459-1-PBS cible IQCG dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: IQCG Protéine recombinante Ag37506
• Nom complet: IQ motif containing G
• Masse moléculaire calculée: 51 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC004816
• Symbole du gène: IQCG
• Identification du gène (NCBI): 84223
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Human IQ motif containing G (IQCG) gene was first reported to be involved in the chromosome translocation in a case of acute T-lymphoid/myeloid leukemia. The expression of Iqcg is prominently enriched in the testis of mice and reveals an ordered expression pattern during spermatogenesis. Iqcg knockout (KO) mice are sterile, due to the severe malformation and total immobility of their spermatozoa. The axoneme in the KO sperm flagellum is disorganized and hardly any typical normal "9+2" pattern, composed of two central microtubules surrounded by nine microtubular doublets, could be found in the KO spermatids. However, the cilia structures in the trachea and oviduct, as well as histological appearances of other major tissues, remain unaffected in the KO mice, suggesting Iqcg's specific role in spermiogenesis (PMID: 24849454).

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