Anticorps Recombinant de lapin anti-IRF3
IRF3 Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain, poisson-zèbre, rat, souris
Applications
WB, IHC, IF/ICC, Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
2H6
N° de cat : 80519-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
80519-1-PBS cible IRF3 dans les applications de WB, IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, poisson-zèbre, rat, souris
Réactivité | Humain, poisson-zèbre, rat, souris |
Hôte / Isotype | Lapin / IgG |
Clonalité | Recombinant |
Type | Anticorps |
Immunogène | Peptide |
Nom complet | interferon regulatory factor 3 |
Masse moléculaire calculée | 47 kDa |
Poids moléculaire observé | 50-60 kDa |
Numéro d’acquisition GenBank | BC009395 |
Symbole du gène | IRF3 |
Identification du gène (NCBI) | 3661 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par protéine A |
Tampon de stockage | PBS only |
Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
The virul-induced expression of interferon(IFN) genes in infected cells implicate in the interplay of several constitutively expressed and virus-activated transcription factors. A family of IFN regulatory factors(IRFs) have been shown to has a role in the transcription of IFN genes as well as IFN-stimulated genes. IRF3 is a novel key transcriptional regulator of type I IFN-dependent immune responses and involves in the innate immune response against DNA and RNA viruses, by binding to the promoters of IFN. It located in the cytoplasm of uninfected cells in an inactive form, and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, could be phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes.