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Anticorps Polyclonal de lapin anti-ISLR2

ISLR2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24814-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using ISLR2 Polyclonal antibody (24814-1-AP)

    WB analysis using 24814-1-AP (same clone as 24814-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24814-1-AP (ISLR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24814-1-PBS in a different storage buffer formulation.

Informations sur le produit

24814-1-PBS cible ISLR2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène ISLR2 Protéine recombinante Ag20518
Nom complet immunoglobulin superfamily containing leucine-rich repeat 2
Masse moléculaire calculée 745 aa, 79 kDa
Poids moléculaire observé79 kDa, 130 kDa
Numéro d’acquisition GenBankBC152429
Symbole du gène ISLR2
Identification du gène (NCBI) 57611
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2), also known as LINX. It is expected to be located in cell membrane and the protein is mainly expressed in brain and testis. While the first knockout mouse had impaired development of the internal capsule and no hydrocephalus, a much more recent independent knockout mouse was shown to additionally have severe hydrocephalus. Although the mechanism remains unclear, it may be related to the role of ISLR2 in reorganizing the cytoskeleton of developing neurons (PMID: 30483960). The calculated molecular weight of ISLR2 is 79 kDa, this target has phosphorylation modification and glycosylation modification. And the 130 kDa band is glycosylated (PMID: 29739947).

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