Anticorps Polyclonal de lapin anti-ITM2C

ITM2C Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 13601-1-PBS

Synonymes

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Galerie de données de validation

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  IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

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Informations sur le produit

13601-1-PBS cible ITM2C dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ITM2C Protéine recombinante Ag3876
• Nom complet: integral membrane protein 2C
• Masse moléculaire calculée: 230aa,26 kDa; 267aa,30 kDa
• Poids moléculaire observé: 30 kDa
• Numéro d’acquisition GenBank: BC025742
• Symbole du gène: ITM2C
• Identification du gène (NCBI): 81618
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

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