Anticorps Monoclonal anti-ITM2C

ITM2C Monoclonal Antibody for IF/ICC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

canin, Humain

Applications

IF/ICC

Conjugaison

CoraLite®594 Fluorescent Dye

CloneNo.

2E8G11

N° de cat : CL594-60095

Synonymes

E25, CT-BRI3, Cerebral protein 14, BRICD2C, BRI3

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Galerie de données de validation

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  IF Staining of MDCK using CL594-60095

  Immunofluorescent analysis of (-20°C Ethanol) fixed MDCK cells using the CoraLite®594-conjugated version of this antibody, CL594-60095 (ITM2C antibody), at dilution of 1:100.

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  IF Staining of HepG2 using CL594-60095

  Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using CoraLite®594 ITM2C antibody (CL594-60095, Clone: 2E8G11 ) at dilution of 1:200.

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Applications testées

• Résultats positifs en IF/ICC: cellules HepG2, cellules MDCK

Dilution recommandée

• Immunofluorescence (IF)/ICC: IF/ICC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

CL594-60095 cible ITM2C dans les applications de IF/ICC et montre une réactivité avec des échantillons canin, Humain

• Réactivité: canin, Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ITM2C Protéine recombinante Ag4409
• Nom complet: integral membrane protein 2C
• Masse moléculaire calculée: 230aa,26 kDa; 267aa,30 kDa
• Poids moléculaire observé: 35 kDa
• Numéro d’acquisition GenBank: BC025742
• Symbole du gène: ITM2C
• Identification du gène (NCBI): 81618
• Conjugaison: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Conditions de stockage: Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

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