Anticorps Polyclonal de lapin anti-ITPR2

ITPR2 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20730-1-PBS

Synonymes

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Galerie de données de validation

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  IHC staining of human small intestine using 20730-1-AP (same clone as 20730-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 20730-1-AP (ITPR2 antibody) at dilution of 1:200 (under 10x lens).. This data was developed using the same antibody clone with 20730-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20730-1-PBS cible ITPR2 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: inositol 1,4,5-triphosphate receptor, type 2
• Masse moléculaire calculée: 308 kDa
• Numéro d’acquisition GenBank: NM_002223
• Symbole du gène: ITPR2
• Identification du gène (NCBI): 3709
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

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