Anticorps Polyclonal de lapin anti-ITPR3

ITPR3 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20729-1-PBS

Synonymes

InsP3R3, IP3R, IP3R 3, IP3R3

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Galerie de données de validation

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  WB analysis using 20729-1-AP (same clone as 20729-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20729-1-AP (ITPR3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse small intestine using 20729-1-AP (same clone as 20729-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse colon using 20729-1-AP (same clone as 20729-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse cerebellum using 20729-1-AP (same clone as 20729-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20729-1-PBS cible ITPR3 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: inositol 1,4,5-triphosphate receptor, type 3
• Masse moléculaire calculée: 304 kDa
• Poids moléculaire observé: 250-300 kDa
• Numéro d’acquisition GenBank: NM_002224
• Symbole du gène: ITPR3
• Identification du gène (NCBI): 3710
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ITPRs family have three members: ITPR1, ITPR2 and ITPR3. For ITPR3, it is associated with cervical squamous cell carcinoma, glioblastoma, cholangiocarcinoma and other cancers. Inositol 1,4, 5-triphosphate receptor type 3 (ITPR3) was found to be apical-located in bile duct cells, and disruption of lipid raft in the segregated bile duct unit (IBDU) redistributes ITPR3 and impairs Ca2+ waves. (PMID: 35580861, PMID:35852334)

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