Anticorps Recombinant de lapin anti-IL-10

IL-10 Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

240430G12

N° de cat : 82191-3-PBS

Synonymes

Il10, IL-10,IL10, 240430G12, CSIF, Il 10

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Galerie de données de validation

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  WB analysis using 82191-3-RR (same clone as 82191-3-PBS)

  Untreated, PMA, LPS and Brefeldin A treated RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 82191-3-RR (Il10 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82191-3-PBS in a different storage buffer formulation.

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Informations sur le produit

82191-3-PBS cible IL-10 dans les applications de WB, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-10 Protéine recombinante Eg0026
• Nom complet: interleukin 10
• Masse moléculaire calculée: 21 kDa
• Poids moléculaire observé: 20 kDa
• Numéro d’acquisition GenBank: NM_010548
• Symbole du gène: Il10
• Identification du gène (NCBI): 16153
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

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