Anticorps Monoclonal anti-Integrin alpha 6

Integrin alpha 6 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2B12A1

N° de cat : 66906-1-PBS

Synonymes

ITGA6, 2B12A1, CD49 antigen-like family member F, CD49f, Integrin alpha-6

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Galerie de données de validation

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  WB analysis of A431 using 66906-1-Ig (same clone as 66906-1-PBS)

  A431 cells were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin alpha-6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

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  WB analysis of JAR using 66906-1-Ig (same clone as 66906-1-PBS)

  JAR cells were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin Alpha 6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

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  WB analysis of human placenta using 66906-1-Ig (same clone as 66906-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin Alpha 6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66906-1-PBS cible Integrin alpha 6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Integrin alpha 6 Protéine recombinante Ag25866
• Nom complet: integrin, alpha 6
• Masse moléculaire calculée: 1073 aa, 119 kDa
• Poids moléculaire observé: 115-120 kDa
• Numéro d’acquisition GenBank: BC136456
• Symbole du gène: Integrin alpha 6
• Identification du gène (NCBI): 3655
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 6 (ITGA6, also known as CD49f or VLA-6) is a 120-kDa single-pass type 1 transmembrane glycoprotein, which combines with the beta 1 subunit (ITGB1, CD29) or beta 4 subunit (ITGB4, CD104) to form heterodimeric laminin receptors (PMID: 1976638; 2351695). Integrin alpha 6 mediates cell-to-cell and cell-to-stroma adhesion. It has also been found in many different stem cell populations and is involved in homing and connecting stem cells to their niches and regulating self-renewal mechanisms in stem cells (PMID: 28494695).

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