Anticorps Recombinant de lapin anti-Integrin alpha 11

Integrin alpha 11 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241351B7

N° de cat : 84695-1-PBS

Synonymes

ITGA11, Integrin alpha-11, 241351B7

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Galerie de données de validation

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  WB analysis using 84695-1-RR (same clone as 84695-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84695-1-RR (Integrin alpha 11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84695-1-PBS in a different storage buffer formulation.

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Informations sur le produit

84695-1-PBS cible Integrin alpha 11 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: integrin, alpha 11
• Masse moléculaire calculée: 133 kDa
• Poids moléculaire observé: 170 kDa
• Numéro d’acquisition GenBank: NM_001004439
• Symbole du gène: ITGA11
• Identification du gène (NCBI): 22801
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 11 (ITGA11) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen. This receptor is involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells (PMID: 11518510). It is also involved in the regulation of myofibroblast phenotypic differentiation during fibrotic diseases (PMID: 29147013).

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